According to the ILAE 2015 Guidelines, how long can Status Epilepticus lead to neuronal injury and functional deficits?

The ILAE 2015 Guidelines indicate that prolonged seizures, specifically Status Epilepticus, have a significant duration after which they can lead to neuronal injury and functional deficits. Research suggests that if seizures persist for approximately 30 minutes or longer, the risk of sustained neuronal damage increases substantially.

This timeframe is critical because, beyond 30 minutes, seizures can lead to cellular injury, which can result in long-term consequences like cognitive deficits, increased seizure susceptibility, and even changes in brain morphology. Intervening before this 30-minute mark is essential in clinical practice to prevent potential irreversible damage and optimize outcomes for individuals experiencing Status Epilepticus.

Understanding this crucial duration helps healthcare providers to make timely decisions in the management of seizures, significantly impacting patient prognosis and long-term health. This guideline underscores the importance of prompt recognition and treatment of Status Epilepticus.